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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Mol Aspects Med. 2015 Feb 23;42:78–90. doi: 10.1016/j.mam.2015.01.005

Figure 1.

Figure 1

The β-cell mass is regulated by a balance of β-cell formation either by neogenesis of β-cells from stem cell/progenitor β-cells or replication from existing β-cells, and β-cell death through β-cell apoptosis. Mathematical and computational models of the net growth of β-cell are governed by the sum of the rates of β-cell neogenesis, replication and death.