Table 1.
Demographics, hippocampal volume and telomerase activity and telomere length
| Controls Telomerase cohort |
MDD Telomerase cohort |
Statistical test Telomerase cohort |
Controls Telomere cohort |
MDD Telomere cohort |
Statistical test Telomere cohort |
|
|---|---|---|---|---|---|---|
| Number | 18 | 25 | -- | 17 | 19 | -- |
| Sex | 61% Female | 68% Female | t=0.46, NS | 59% female | 63% female | t=0.26, NS |
| Age (years) | 34.9 ± 9.6 | 37.8 ± 12.0 | t=0.84, NS | 37.9 ± 12.3 | 37.5 ± 11.9 | t=0.12, NS |
| Body mass index (kg/m)2 |
24.8 ± 4.0 | 25.0 ± 4.4 | t=0.21, NS | 24.9 ± 4.0 | 24.6 ± 4.1 | t=0.21, NS |
| Hamilton Depression Rating Scale-17 item |
N/A | 19.2 ± 0.6 (range: 17- 26) |
N/A | N/A | 19.4 ± 0.7 (range: 17-26) |
N/A |
| Raw hippocampal volume |
7.30 ± 0.97 | 7.50 ± 1.13 | F=0.34*, NS | 0.24 ± 0.98 | 7.38 ± 1.15 | F=0.52*, NS |
| Intracranial volume (ICV) |
1585.7 ± 197.6 | 1624.9 ± 128.3 | F=0.87*, NS | 1624.4 ± 190.2 | 1627.6 ± 108.8 | F=0.79*, NS |
| Total hippocampal volume, Normed to Intra-cranial volume (ICV) |
4.64 ± 0.60 | 4.60 ± 0.71 | F=0.00*, NS | 4.48 ± 0.55 | 4.52 ± 0.79 | F=0.02*, NS |
| PBMC Telomerase activity (units/10,000 cells); Z-scores |
Raw value: 7.03 ± 0.60 Z-score: −0.250 ± 1.04 |
Raw value: 7.83 ± 5.90 Z-score: 0.242 ± 0.897 |
Z-score: F=5.26*, p=0.025 |
-- | -- | -- |
| Leukocyte telomere length (base pairs); Z- scores |
-- | -- | -- | Raw value (T/S): 0.851 ± 0.090 Z-score: 0.062 ± 0.749 |
Raw value (T/S): 0.881 ± 0.175 Z-score: 0.006 ± 1.149 |
Z-score: F=0.48*, NS |
*
Analysis of variance, controlling for age and sex.
Values are means ± SD.