Table 2. Determinants of log-hepcidin-level (linear regression analyses).
| univariate | multivariate | ||
|---|---|---|---|
| model 1 | model 2 | ||
| age [10 yrs] | -0.02 (-0.09; 0.05) | 0.002, p = 0.5 | -- |
| gender, male | 0.24 (0.08; 0.41) | -0.11, p = 0.13 | 0.21 (0.04; 0.37) |
| type 2 diabetes | -0.09 (-0.37; 0.19) | -0.03, p = 0.7 | -- |
| EPO [log (U/L)] | -0.02 (-0.39; -0.09) | -0.007 (-0.04; -0.01), p = 0.065 | -0.01 (-0.02; 0.00) |
| GFR [10 ml/min/1.73 m2] | -0.04 (-0.07; -0.004) | -0.04 (-0.06; -0.01) | -0.03 (-0.06; -0.01) |
| proteinuria [log(mg/day)] | 0.05 (-0.007; 0.11) | 0.02, p = 0.4 | -- |
| hemoglobin [g/L] | -0.005 (-0.05; 0.04) | -0.01, p = 0.8 | -- |
| ferritin [log(μg/L)] | 0.48 (0.41; 0.55) | 0.46 (0.39; 0.53) | 0.45 (0.38; 0.52) |
| CRP [log(mg/dl)] | 0.03 (-0.03; 0.10) | -- | 0.02, p = 0.6 |
| albumin [(g/dL)2] | 0.002 (-0.02; 0.02) | -- | -0.002, p = 0.7 |
| history of CVD | -0.13 (-0.31; 0.05) | -- | -0.05, p = 0.5 |
| hypertension | 0.19 (-0.02; 0.41) | -- | 0.18 (0.02; 0.35) |
| hyperlipidemia | 0.21 (0.05; 0.39) | -- | 0.13 (0.00; 0.25) |
Legend: data are beta-coefficients (95% CI), displayed bolded if p<0.05; multivariate linear regression models were built stepwise (model 1: basic patient characteristics, model 2: additional markers of inflammation and clinical variables), while eliminating variables with p>0.1 within each model (beta-coefficients and p-values are displayed before variables left the model); abbreviations: CI, confidence interval; EPO, endogenous erythropoietin; CVD, cardiovascular disease; GFR, glomerular filtration rate; CRP, C-reactive protein;