Table 3. Determinants of mortality (Cox proportional hazards analysis).
| univariate | multivariate | ||
|---|---|---|---|
| model 1 | model 2 | ||
| hepcidin [10 ng/ml] | 1.024 (0.951; 1.102) | 1.513 (1.136; 2.015) | 1.491 (1.095; 2.029) |
| EPO [log (U/L)] | 1.497 (0.867; 2.585) | 2.612 (0.972; 7.020) | 2.466 (0.884; 6.877) |
| hepcidin * logEPO | -- | 0.846 (0.759; 0.944) | 0.858 (0.763; 0.9763) |
| age [10 yrs] | 1.917 (1.413; 2.602) | 2.225 (1.399; 3.538) | 1.982 (1.292; 3.042) |
| gender, male | 1.982 (1.089; 3.601) | 2.030 (0.873; 4.721) | 2.03, p = 0.10 |
| type 2 diabetes | 3.715 (1.015; 13.60) | 0.78, p = 0.8 | -- |
| GFR [10 ml/min/173m2] | 0.718 (0.624; 0.826) | 0.96, p = 0.7 | -- |
| proteinuria [log(mg/day)] | 1.487 (1.229; 1.799) | 1.538 (1.227; 1.929) | 1.625 (1.305; 2.023) |
| hemoglobin [g/L] | 0.829 (0.725; 0.949) | 0.99, p = 0.9 | -- |
| CRP [log (mg/dl)] | 1.509 (1.194; 1.908) | 1.592 (1.163; 2.179) | 1.566 (1.133; 2.165) |
| albumin [(g/dl)] | 0.425 (0.276; 0.655) | 0.74, p = 0.5 | -- |
| history of CVD | 3.663 (2.041; 6.571) | 1.63, p = 0.2 | -- |
| hypertension | 1.216 (0.566; 2.611) | -- | -- |
| hyperlipidemia | 1.055 (0.598; 1.864) | -- | -- |
| ferritin [log(μg/L)] | 0.973 (0.715; 1.324) | -- | -- |
Legend: data are hazard ratios (HR) (95% confidence interval, CI), displayed bolded if p<0.05; multivariate Cox models were built with backwards selection (model 1: pexclusion>0.10, model 2: pexclusion>0.05), accounting for variables significant (p<0.05) in univariate associations (HRs and p-values are displayed before variables left the model)