Table 4. Determinants of progression of CKD (Cox proportional hazards analysis).
| univariate | multivariate | |
|---|---|---|
| hepcidin [10 ng/ml] | 1.179 (1.095; 1.270) | 1.134 (1.041; 1.235) |
| EPO [log(U/L)] | 1.463 (0.797; 2.687) | 1.13, p = 0.8 |
| age [10 yrs] | 1.330 (1.000; 1.768) | 0.92, p = 0.7 |
| gender, male | 2.100 (1.083; 4.071) | 1.53, p = 0.4 |
| type 2 diabetes | 2.432 (0.719; 8.229) | -- |
| GFR [10 ml/min/173m2] | 0.431 (0.330; 0.561) | 0.545 (0.370; 0.802) |
| proteinuria [log(mg/day)] | 2.202 (1.740; 2.786) | 1.542 (1.133; 2.101) |
| hemoglobin [g/L] | 0.652 (0.570; 0.746) | 0.678 (0.503; 0.915) |
| CRP [log (mg/dl)] | 1.779 (1.342; 2.358) | 1.28, p = 0.2 |
| albumin [g/dl] | 0.325 (0.218; 0.484) | 0.301 (0.119; 0.762) |
| history of CVD | 2.771 (1.488; 5.162) | 2.345 (1.035; 5.316) |
| hypertension | 1.526 (0.596; 3.907) | -- |
| hyperlipidemia | 0.894 (0.475; 1.683) | -- |
| ferritin [log(μg/L)] | 1.313 (0.918; 1.878) | -- |
Legend: data are hazard ratios (HR) (95% confidence interval, CI), displayed bolded if p<0.05, the multivariate Cox model was built with backwards selection (pexclusion>0.05), accounting for variables significant (p<0.05) in univariate association and EPO (HRs and p-values are displayed before variables left the model)