Table 2.
Odds Ratios (95% Confidence Intervals) for each offspring cardiometabolic risk factor meeting or exceeding the 75th percentile at 7 years of age associated with a 1 mmol/L increase in maternal pregnancy glucose level, CHAMACOS study, 1999-2008.
| Cardio-metabolic risk factor ≥ 75th percentile |
Unadjusted | Model 1a | Model 2d | Model 3c |
|---|---|---|---|---|
| Non-fasting total cholesterol | 1.06 (0.85 - 1.33) |
1.12 (0.88-1.42) |
1.17 (0.91-1.49) |
1.13 (0.88-1.45) |
| Non-fasting triglycerides | 1.16 (0.93 - 1.45) |
1.19 (0.94-1.51) |
1.19 (0.93-1.51) |
1.17 (0.91-1.49) |
| Waist Circumference d | 1.17 (0.95-1.44) |
1.14 (0.92-1.42) |
1.15 (0.92-1.42) |
1.19 (0.95-1.49) |
| Waist Circumference e |
1.25
(1.04 - 1.52) |
1.26
(1.04-1.54) |
1.24
(1.01-1.52) |
1.2
(1.02-1.54) |
| Diastolic blood pressure |
1.29
(1.04 - 1.60) |
1.35
(1.08-1.69) |
1.35
(1.08-1.69) |
1.39
(1.10-1.75) |
| Systolic blood pressure |
1.31
(1.07 - 1.61) |
1.37
(1.10-1.71) |
1.38
(1.11-1.72) |
1.38
(1.10-1.73) |
Model 1 adjusted for child’s sex; maternal pre-pregnancy obesity (BMI ≥ 30 kg/m2), sugar sweetened beverage consumption during pregnancy (times per week, continuous), gestational weight gained prior to the glucose test (continuous), gestational age at weight measurement (continuous), smoking (yes/no), and poverty (at/below poverty line vs. above).
Model 2 adjusted for Model 1 covariates, plus infant birthweight (continuous).
Model 3 adjusted for Model 2 covariates, plus infant’s gestational age at birth (continuous).
Based on the study cohort sex-specific distributions; child’s sex dropped from the adjusted models
Based on a nationally representative sample of 7 year old Mexican-American children, sex-specific; child’s sex dropped from the adjusted models