Fig 1. Signaling cascades initiated by ligand binding by TLR3 and TLR4 in human (left) and mouse (right).

Proteins are shown as colored shapes, LPS as a cluster of open circles, and dsRNA as intertwined black lines. Entities and interactions for which there is not consistent evidence of conservation between species are shown as dotted outlines in the species for which there is no evidence for their function.