Table 1. TLR3 and TLR4 complexes.
| parent PRO ID | name | human PRO ID | human Reactome ID | mouse PRO ID |
|---|---|---|---|---|
| PR:000037302 | viral dsRNA:TLR3 complex | PR:000037303 | REACT_7159 | PR:000037304 |
| PR:000037306 | ticam1:viral dsRNA:TLR3 complex | PR:000037307 | REACT_7381 | PR:000037308 |
| PR:000037309 | traf3:ticam1:activated TLR3 complex | PR:000037310 | REACT_124037 | PR:000037311 |
| PR:000037343 | traf6:ticam1:activated TLR3 complex | PR:000037344 | REACT_25948 | PR:000037471 |
| PR:000036003 | MD2:TLR4 complex | PR:000036004 | REACT_7105 | PR:000036005 |
| PR:000036076 | MD2:LPS:TLR4 complex | none | none | PR:000036077 |
| PR:000025497 | lipopolysaccharide receptor complex 3 | PR:000025773 | REACT_124771 | PR:000037476 |
| PR:000025498 | lipopolysaccharide receptor complex 4 | PR:000037479 | REACT_124771 | none |
| PR:000027202 | ticam2:activated TLR4 complex | PR:000028678 | REACT_7083 | PR:000027204 |
| PR:000027205 | ticam1:ticam2:activated TLR4 complex | PR:000027208 | REACT_7861 | PR:000027207 |
| PR:000028681 | traf3:ticam1:ticam2:activated TLR4 complex | PR:000036022 | REACT_124037 | PR:000028683 |
| PR:000028679 | traf6:ticam1:ticam2:activated TLR4 complex | PR:000028680 | REACT_25948 | PR:000035710 |
| PR:000036078 | TIRAP:PIP2:activated TLR4 complex | PR:000036135 | REACT_152404 | PR:000027196 |
| PR:000037472 | TIRAP:PIP2:BTK:activated TLR4 complex | PR:000037447 | REACT_124673 | PR:000037477 + |
| PR:000037472 | pTIRAP:PIP2:BTK:activated TLR4 complex | PR:000037448 | REACT_125282 | PR:000027217 |
| PR:000037488 | MyD88:TIRAP:PIP2:BTK:activated TLR4 complex | PR:000037446 | REACT_7694 | PR:000037481 + |
| PR:000025784 | MyD88:Mal:activated TLR4 receptor | none | none | PR:000027174 |
+ All PRO annotations are based on experimental evidence (Evidence code ontology ECO:0000269) except ones marked with asterisks, which are based on reconstruction of a biological system (ECO:0000088)
For each complex involved in the initial steps of TLR3 or TLR4 signaling (Table 1), the PRO identifier of its species-agnostic form (parent PRO ID) is listed, together with its PRO name and the PRO identifiers of its human and mouse forms and the Reactome identifier of its human form. A version of this table with hyperlinks to the databases embedded in each identifier is available in S2 Table.