Fig 2. Compounds from the TCAMS (1–6) and Malaria Box (7–9) libraries that were selective inhibitors of glucose, but not proline, transport.

Dose-response curves for inhibition of uptake of 100 μM [³H] D-glucose by each compound were performed for PfHT and GLUT1, and the IC₅₀ values are tabulated. SI_glucose indicates Specificity Index for glucose uptake and is IC₅₀ for GLUT1/IC₅₀ for PfHT. The reported EC₅₀ values (PubChem web site, http://pubchem.ncbi.nlm.nih.gov/) for inhibition of growth of P. falciparum strain 3D7 intraerythrocytic forms by each compound are also tabulated.