Table 2. Meta-analysis results for the five studied polymorphisms and RSA risk.

Gene polymorphism	Inherited model	Heterogeneity-test		Analysis model a	Pooled OR (95% CI)	P
		P for Q test	I2(%)
rs2010963	Codominant(C vs. G)	0.22	29	FEM	1.16 [1.03, 1.31]	0.01
	Homozygous(CC vs. GG)	0.42	0	FEM	1.36 [1.06, 1.74]	0.02
	Heterozygous(CC vs. GC)	0.87	0	FEM	1.20 [0.94, 1.52]	0.14
	Dominant(CC+GC vs. GG)	0.25	25	FEM	0.85 [0.72, 1.01]	0.06
	Recessive(CC vs. GC+GG)	0.68	0	FEM	0.79 [0.63, 0.98]	0.04
rs3025020	Codominant(C vs. T)	0.76	0	FEM	0.57 [0.49, 0.67]	<0.001
	Homozygous(CC vs. TT)	0.05	0	FEM	0.30 [0.22, 0.41]	<0.001
	Heterozygous(TT vs. CT)	0.11	55	REM	3.20 [2.02, 5.07]	<0.001
	Dominant(TT+CT vs. CC)	0.92	0	FEM	0.68 [0.55, 0.84]	0.0004
	Recessive(TT vs. CT+CC)	0.19	39	FEM	3.22 [2.43, 4.27]	<0.001
rs3025039	Codominant(C vs. T)	0.02	61	REM	0.72 [0.56, 0.93]	0.01
	Homozygous(CC vs. TT)	0.20	30	FEM	0.57 [0.36, 0.90]	0.02
	Heterozygous(TT vs. CT)	0.58	0	FEM	1.22 [0.75, 1.98]	0.43
	Dominant(TT+CT vs. CC)	0.06	51	REM	0.69 [0.53, 0.89]	<0.005
	Recessive(TT vs. CT+CC)	0.28	20	FEM	1.60 [1.01, 2.54]	0.05
rs699947	Codominant(C vs. A)	0.04	58	REM	0.99 [0.82, 1.20]	0.92
	Homozygous(CC vs. AA)	0.11	44	FEM	1.04 [0.81, 1.32]	0.78
	Heterozygous(AA vs. CA)	0.82	0	FEM	1.05 [0.82, 1.34]	0.70
	Dominant(AA+CA vs.CC)	0.04	58	REM	1.03 [0.79, 1.33]	0.85
	Recessive(AA vs. CA+CC)	0.42	0	FEM	1.01 [0.81, 1.27]	0.91
rs1570360	Codominant(G vs. A)	0.002	72	REM	0.88 [0.69, 1.12]	0.029
	Homozygous(GG vs. AA)	0.02	61	REM	0.72 [0.43, 1.21]	0.21
	Heterozygous(GG vs. GA)	0.02	60	REM	0.98 [0.75, 1.28]	0.86
	Dominant(GG+GA vs. AA)	0.07	48	FEM	1.49 [1.12, 1.96]	0.005
	Recessive(GG vs. GA+AA)	0.005	68	REM	0.91 [0.69, 1.21]	0.52

^a REM: random-effect model. FEM: fixed-effect model.

P-value of overall effect.