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. 2015 Apr 20;10(4):e0124409. doi: 10.1371/journal.pone.0124409

Fig 3. Transactivational defects caused by PITX2 mutation.

Fig 3

Transcriptional activation of atrial natriuretic factor promoter driven luciferase reporter in CHO cells by wild-type or mutant PITX2, alone or in combination, showed that the mutant PITX2 did not transactivate gene expression. Data are derived from three independent experiments repeated in triplicate. Mean fold activation and standard deviations are shown. ** and * represent P<0.001 and P<0.01, respectively, when compared with wild-type PITX2.