Table 1. Test of heterogeneity of selective pressure along genes.

Gene	Model	Parameter estimates	Log likelihood (L)	2lnΔL a
TLR1	M0	ω = 0.3788	-2648.2197	35.9222**
	M3	p0 = 0.2608, ω0 = 0.2002, p1 = 0.7235, ω1 = 0.2002, p2 = 0.0157, ω2 = 20.3741	-2630.2586
TLR2	M0	ω = 0.4383	-2762.6134	17.2620**
	M3	p0 = 0.0695, ω0 = 0.2757, p1 = 0.9142, ω1 = 0.2757, p2 = 0.0163, ω2 = 11.1174	-2753.9824
TLR3	M0	ω = 0.2649	-2952.9019	0.0000 NS
	M3	p0 = 0.2240, ω0 = 0.2649, p1 = 0.3124, ω1 = 0.2650, p2 = 0.4635, ω2 = 0.2650	-2952.9019
TLR6	M0	ω = 0.4692	-2695.5056	30.8540**
	M3	p0 = 0.3864, ω0 = 0.0000, p1 = 0.5357, ω1 = 0.0000, p2 = 0.0780, ω2 = 6.7044	-2680.0786
TLR7	M0	ω = 0.1087	-3980.3407	1.2288 NS
	M3	p0 = 0.4460, ω0 = 0.0000, p1 = 0.2772, ω1 = 0.0000, p2 = 0.2768, ω2 = 0.3977	-3979.7263
TLR8	M0	ω = 0.3085	-3985.5001	21.3048**
	M3	p0 = 0.7187, ω0 = 0.0000, p1 = 0.1417, ω1 = 0.0000, p2 = 0.1397, ω2 = 2.3685	-3974.8477

p₀ is proportion of sites where ω <1(ω₀), p₁ is proportion of sites where ω = 1(ω₁).

p₂ is proportion of sites where ω>1(ω₂).

^a Twice the difference in log-likelihood values between models M0 and M3.

**p<0.01.

^NSNot significant.