Table 4. Positively selected sites predicted to affect TLR function based on human Swiss Prot entries and site location in three dimensional TLR structures.

Gene	Codon	Equivalent codon in human	Functional Information
TLR1	117	113	In the region (110–132) of cysteine residues participating in disulphide bonds a
	434	430	Adjacent to a glycosylation site (429) a
	559	555	Adjacent to site of SNP (Tyr554Cys) that leads to marked impairment of NF-kB activation b
TLR2	338	337	LRR12—involved in ligand binding a
TLR6	334	334	LRR12—involved in TLR2-TLR6 heterodimerization c

^{a, b, c} represent references:

^a [22],

^b[41],

^c [24].