TABLE 1.
Geometric Mean | Geometric Mean Ratio (90% CI) | |||
---|---|---|---|---|
PK Parameter | N | Pitavastatin With EFV | Pitavastatin Only | Pitavastatin With EFV/Pitvastatin Only |
AUC0-τ, ng·h·mL−1 | 14 | 76 | 85.3 | 0.89 (0.73 to 1.09) |
Cmax, ng/mL | 14 | 18.8 | 15.6 | 1.20 (0.79 to 1.83) |
Tmax, h* | 14 | 1.5 (1.0 to 2.3) | 2.0 (0.9 to 3.0) | |
EFV With Pitavastatin | EFV Only | EFV With Pitavastatin/EFV Only | ||
AUC0-τ, µg·h·mL−1 | 14 | 44.4 | 49.5 | 0.90 (0.75 to 1.06) |
Cmax, µg·mL−1 | 14 | 3.72 | 4.15 | 0.90 (0.66 to 1.22) |
Tmax, h* | 14 | 1.5 (1.0 to 2.3) | 2.0 (0.9 to 3.0) |
Tmax reported as median (IQR).