TABLE 2.
Geometric Mean | Geometric Mean Ratio (90% CI) | |||
---|---|---|---|---|
PK Parameter | N | Pitavastatin With DRV/r | Pitavastatin Only | Pitavastatin With DRV/r/Pitavastatin Only |
AUC0-τ, ng·h·mL−1 | 10 | 56.9 | 62.8 | 0.91 (0.78 to 1.06) |
Cmax, ng/mL | 10 | 23.2 | 24 | 0.93 (0.72 to 1.19) |
Tmax, h* | 10 | 0.5 (0.5 to 1.0) | 0.5 (0.5 to 0.5) | |
DRV/r With Pitavastatin | DRV/r Only | DRVr With Pitavastatin/DRV/r Only | ||
AUC0-τ, µg·h·mL−1 | 14 | 76.7 | 70.9 | 1.08 (0.96 to 1.22) |
Cmax, µg/mL | 14 | 6.78 | 6.61 | 1.03 (0.91 to 1.15) |
Tmax, h* | 14 | 0.5 (0.5 to 1.0) | 0.5 (0.5 to 0.5) |
Tmax reported as median (IQR).