Table 3.

Best QOL Instruments for Specific Uses

Setting	Best QOL Instrument(s)
Clinical Care	Global QOL:
	WHOQOL-BREF
	MQOL
	SEIQoL and SEIQoL-DW
	ALSSQOL-R
Comparisons of Groups	Global QOL:
	WHOQOL-BREF
	MQOL
	ALSSQOL-R
Therapeutic Intervention	HRQOL  Specific for the outcome of the intervention
Powerful or Toxic Therapeutic Intervention	Global QOL and HRQOL specific for the outcome of the intervention

ALSSQOL-R = ALS-specific QOL Instrument – Revised; HRQOL = Health-related QOL; MQOL = McGill QOL Questionnaire; SEIQoL-DW = Schedule for the evaluation of individual quality of life – direct weighting; WHOQOL-BREF = World Health Organization Quality of Life 26-item questionnaire