Skip to main content
. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Science. 2014 Jul 10;345(6198):1255903. doi: 10.1126/science.1255903

Figure 4. DMRs regain methylation late during PGC reprogramming and retain nucleosomes in mature sperm.

Figure 4

A) Methylation level of hypomethylated (green) and hypermethylated (red) DMRs in our data set versus the whole genome (grey) in normal PGCs (25) and mature sperm from adult males (26). Hypermethylated DMRs act as an additional negative control since they did not validate. E13.5 and E16.5 are male PGCs. E6.5 and E11.5: mixed sex PGCs (25).

B) Nucleosome enrichment (27) at 5 representative hypomethylated DMRs.