Table 4.
Top 10 GO and KEGG enriched categories for stabilizing and diversifying selection
| Mode | Category | KEGG term | Adjusted P value | GO category | Ontology | GO term | Adjusted P value |
|---|---|---|---|---|---|---|---|
| Stabilizing | 3040 | Spliceosome | 6.47E-23 | GO:0016071 | BP | mRNA metabolic process | 6.29E-79 |
| Stabilizing | 3010 | Ribosome | 3.19E-22 | GO:0044260 | BP | Cellular macromolecule metabolic process | 3.99E-65 |
| Stabilizing | 3013 | RNA transport | 2.75E-15 | GO:0005515 | MF | Protein binding | 8.51E-61 |
| Stabilizing | 3050 | Proteasome | 6.39E-15 | GO:0003723 | MF | RNA binding | 1.30E-59 |
| Stabilizing | 4141 | Protein processing in endoplasmic reticulum | 6.39E-15 | GO:0044267 | BP | Cellular protein metabolic process | 3.21E-59 |
| Stabilizing | 190 | Oxidative phosphorylation | 1.03E-12 | GO:0043170 | BP | Macromolecule metabolic process | 5.79E-57 |
| Stabilizing | 5016 | Huntington's disease | 1.23E-11 | GO:0044237 | BP | Cellular metabolic process | 4.46E-55 |
| Stabilizing | 5012 | Parkinson's disease | 3.76E-11 | GO:0008150 | BP | Biological process | 2.03E-52 |
| Stabilizing | 4120 | Ubiquitin mediated proteolysis | 4.53E-09 | GO:0044265 | BP | Cellular macromolecule catabolic process | 1.00E-50 |
| Stabilizing | 3015 | mRNA surveillance pathway | 2.02E-07 | GO:0009987 | BP | Cellular process | 2.03E-50 |
| Diversifying | 4060 | Cytokine-cytokine receptor interaction | 1.47E-08 | GO:0044707 | BP | Single-multicellular organism process | 1.66E-15 |
| Diversifying | 4080 | Neuroactive ligand-receptor interaction | 1.88E-06 | GO:0032501 | BP | Multicellular organismal process | 2.66E-15 |
| Diversifying | 5144 | Malaria | 0.000537871 | GO:0007155 | BP | Cell adhesion | 5.78E-14 |
| Diversifying | 5323 | Rheumatoid arthritis | 0.000823394 | GO:0022610 | BP | Biological adhesion | 5.78E-14 |
| Diversifying | 4514 | Cell adhesion molecules (CAMs) | 0.008404931 | GO:0008083 | MF | Growth factor activity | 4.19E-12 |
| Diversifying | 5140 | Leishmaniasis | 0.010748899 | GO:0005539 | MF | Glycosaminoglycan binding | 6.15E-12 |
| Diversifying | 5143 | African trypanosomiasis | 0.014357322 | GO:0005125 | MF | Cytokine activity | 7.81E-12 |
| Diversifying | 4340 | Hedgehog signaling pathway | 0.014357322 | GO:0097367 | MF | Carbohydrate derivative binding | 2.26E-11 |
| Diversifying | 260 | Glycine, serine and threonine metabolism | 0.027173137 | GO:0008201 | MF | Heparin binding | 2.26E-11 |
| Diversifying | 4976 | Bile secretion | 0.027173137 | GO:0005102 | MF | Receptor binding | 4.08E-11 |
Enriched pathways for stabilizing and diversifying genes. The table provides the selective mode, the category identifier (as in Table 3), the associated term or brief description, and the Benjamini-Hochberg adjusted P value.