Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 11;6:17. doi: 10.1186/s13326-015-0013-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Papatheodorou et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Three challenges when representing and comparing phenotypes. The diagram illustrates the three challenges that need to be overcome in order to link gene expression and phenotypes using pathways: (A) the integration across the different levels of complexity within an organism, (B) the integration across species, and (C) the frequencies of occurrences of phenotypes (quantification) – purple colour represents individuals possessing phenotype of interest (examples in parentheses taken from Angelman syndrome in OrphaNet)