Table 1.
Top 10 age-group associated CpG sites from the regression model
| ProbeID | Gene | betareg estimate | betareg p-value | Δβ | Wilcoxon p-value |
|---|---|---|---|---|---|
| cg16867657 | ELOVL2 | 1.023 | 6.38E-66 | 0.243 | 1.53E-10 |
| cg16762684 | MBP | -1.486 | 4.74E-64 | -0.168 | 1.53E-10 |
| cg11344352 | ERCC1 | -1.202 | 9.15E-63 | -0.153 | 1.53E-10 |
| cg17110586 | na | 0.895 | 1.46E-59 | 0.200 | 1.53E-10 |
| cg04875128 | OTUD7A | 1.514 | 7.2E-58 | 0.279 | 1.53E-10 |
| cg08262002 | LDB2 | -0.710 | 2.72E-55 | -0.197 | 1.53E-10 |
| cg18618815 | COL1A1 | -0.941 | 1.78E-52 | -0.225 | 1.53E-10 |
| cg00748589 | na | 0.864 | 1.36E-51 | 0.179 | 1.53E-10 |
| cg15416179 | MAP2K3 | -1.131 | 2.38E-51 | -0.187 | 1.53E-10 |
| cg12065799 | RRAGC | -0.823 | 8.15E-51 | -0.088 | 1.53E-10 |
| cg23479922 | MARCH11 | 0.940 | 4.07E-49 | 0.263 | 1.53E-10 |
| cg07544187 | CILP2 | 1.541 | 2.35E-48 | 0.252 | 1.53E-10 |
| cg09038267 | C10orf26 | 1.227 | 1.48E-47 | 0.150 | 1.53E-10 |
| cg13033938 | IP6K1 | -0.699 | 7.54E-47 | -0.061 | 1.53E-10 |
| cg19283806 | CCDC102B | -1.253 | 9.82E-47 | -0.267 | 1.53E-10 |
| cg07547549 | SLC12A5 | 0.900 | 5.02E-46 | 0.245 | 1.53E-10 |
| cg01949403 | APOL3 | 0.807 | 7.53E-46 | 0.111 | 1.53E-10 |
| cg01243823 | NOD2 | -1.280 | 7.9E-46 | -0.232 | 1.53E-10 |
| cg22242842 | na | -0.952 | 1.99E-44 | -0.206 | 1.53E-10 |
| cg06007201 | FAM38A | -0.932 | 5.65E-44 | -0.156 | 1.53E-10 |
CpG sites with most significant association to age group in the beta regression models (betareg). To clarify, Δβ refers to difference in the median of DNA methylation values between nonagenarians and young controls (difference in β-value), whereas betareg estimate refers to the estimate obtained from a regression model termed beta regression. Thus the absolute value of betareg estimate and the absolute value of Δβ for a given CpG site are not directly comparable, only the signs of the values are.