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. 2015 Mar 19;6(1):36. doi: 10.1186/s13287-015-0026-0

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© Zhang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CCR5-overexpressing endothelial progenitor cell treatment decreased interleukin-6 (IL-6) and matrix metalloproteinase 9 (MMP9) expression on the atherosclerotic plaques. (A) Immunostaining of IL-6 on the aortic root plaques at 6 weeks after treatment with phosphate-buffered saline (PBS), Lenti-EGFP, or Lenti-CCR5. (B) Quantitative analysis of the IL-6 expression in (A) (n = 6, *P <0.05, **P <0.01). (C) Immunostaining of MMP9 on the aortic root plaques at 6 weeks after treatment with PBS, Lenti-EGFP, or Lenti-CCR5. (D) Quantitative analysis of the MMP9 expression in (C) (n = 6, *P <0.05, **P <0.01). Bars represent mean ± standard deviation. CCR5, chemokine (C-C motif) receptor 5; EGFP, enhanced green fluorescent protein; n.s., non-significant.