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. 2015 Mar 21;6(1):41. doi: 10.1186/s13287-015-0042-0

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© Li et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Directedness, net displacement, and migration speed of neural stem cell-derived oligodendrocyte precursor cell (NSC-OPC) migration in electric fields (EFs). (A) Circular histogram. The migrated ARPC2^+/+ NSC-OPCs showed clear biased distribution in EFs (200 mV/mm). It indicated the cathodal migration of the cells. The range of interval is 10 degrees. (B) Increase in average cosine (directedness) of ARPC2^+/+ NSC-OPCs when field strength increased from 50 to 200 mV/mm. No change in average cosine (directedness) of ARPC2^−/− NSC-OPCs in EFs from 50 to 200 mV/mm was observed. (C) More significant net cathodal displacement of ARPC2^+/+ NSC-OPCs when EF increased from 50 to 200 mV/mm. No change in net displacement of ARPC2^−/− NSC-OPCs when EF increased from 50 to 200 mV/mm was observed. *P <0.05, compared with ARPC2^+/+ NSC-OPCs without EF stimulation. #<0.05, compared with ARPC2^+/+ NSC-OPCs in EFs with field strength of 100mM/mm. (D) Analysis of cell migration speed in EFs. EFs did not significantly change migration speed of either ARPC2^+/+ NSC-OPCs or ARPC2^−/− NSC-OPCs. *P <0.05, compared with ARPC2^−/− NSC-OPCs.