Skip to main content
. Author manuscript; available in PMC: 2016 Mar 10.
Published in final edited form as: Biochemistry. 2015 Feb 26;54(9):1849–1857. doi: 10.1021/bi501491z

Figure 9.

Figure 9

BER enzymes prevent abasic sites in duplex DNA from cross-linking by binding tightly to the free abasic sites (AAG, AlkA) or by reacting irreversibly with them (APE1, Nth). An abasic pyrrolidine nucleotide is flipped into the active site of AAG in the structure that is shown.51