Table 6.

Study design: group allocation, time point and dose of inoculation and time point of necropsy

Start of inoculation period	3-5 dpn			41-43 dpn
Group	K1	V1	V2	K2	V3	V4
Number of animals (n)	6	7	7	6	6	7
Inoculation dose per day (mg bwm)	-	10	20	-	10	20
Average bacterial counts/mL	-	2.08 ± 0.57x107		-	1.62 ± 0.73x107
Average bacterial counts/inoculum	-	2.08x108	4.16x108	-	1.62x108	3.24x108
Total inoculation dose	-	2.08x109	4.16x109	-	1.62x109	3.24x109
Time of necropsy (wpi)	48a)	48	49b)	46	47	48c)

dpn, days post natum; bwm, bacterial wet mass; wpi, weeks post infection; ^a)one animal was necropsied at 39 wpi; ^b)one animal each died at 37 and 39 wpi, one animal each was necropsied at 37 and 38 wpi; ^c)one animal was necropsied at 35 wpi.