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. 2015 Mar 19;10:13. doi: 10.1186/s13024-015-0007-x

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© Song et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Disrupted circadian rhythm in 5XFAD mice. (A & B) Altered rhythmic waveform of home cage activity and body temperature in two-month-old 5XFAD mice in light–dark (LD) and dark-dark (DD) cycle. (C & D) Altered rhythmic waveform of home cage activity and body temperature in eight-month-old 5XFAD mice in LD and DD cycle.