Table 3.

The distribution of (−)-[¹¹C]2 and (−)-[¹¹C]6 in Sprague Dawley control rats and rats pretreated using a σ ligand, YUN-143, or cold (±)-2 at 30 min postinjection

Organ	(−)-[11C]2			(−)-[11C]6
	Control	σ block	VAChT block	Control	VAChT block
Blood	0.309±0.017	0.339±0.075	0.271±0.093	0.162±0.009	0.170±0.014
Lung	1.045±0.091	0.928±0.199	0.927±0.319	0.701±0.065	0.782±0.055
Liver	2.448±0.272	1.962±0.306	2.234±0.258	1.455±0.091	1.048±0.698
Spleen	0.662±0.083	0.515±0.095	0.587±0.154	0.551±0.026	0.599±0.056
Kidney	0.785±0.119	0.751±0.093	0.770±0.113	0.854±0.051	0.892±0.057
Pancreas	1.200±0.105	0.799±0.133	0.764±0.075	0.694±0.192	0.577±0.018
Muscle	0.208±0.010	0.208±0.025	0.242±0.037	0.204±0.013	0.205±0.004
Fat	1.768±0.436	2.020±0.598	1.539±0.761	0.375±0.031	0.314±0.092
Heart	0.290±0.016	0.298±0.048	0.245±0.041	0.250±0.034	0.250±0.019
Cerebellum	0.317±0.047	0.216±0.020	0.214±0.062	0.223±0.016	0.207±0.020
Brain stem	0.437±0.039	0.293±0.037	0.276±0.048	0.257±0.019	0.236±0.020
Thalamus	0.370±0.043	0.280±0.036	0.234±0.038	0.275±0.008	0.235±0.025
Striatum	0.546±0.071	0.629±0.060*	0.276±0.065**	0.342±0.060	0.251±0.013***
Cortex	0.331±0.128	0.292±0.047	0.239±0.100	0.202±0.062	0.218±0.030
Hippocampus	0.350±0.042	0.288±0.020	0.220±0.058	0.222±0.025	0.237±0.014
Total brain	0.370±0.031	0.308±0.021	0.242±0.062	0.247±0.036	0.233±0.014

%ID/g values (mean ± SD) with n = 4 rats per group. p value was determined by using two-tailed paired Student’s t test for the striatum uptake in control rats versus rats pretreated with the blocking agent

^*p>0.05;

^**p=0.0014;

^***p=0.025