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. 2015 Feb 25;4(2):e981457. doi: 10.4161/2162402X.2014.981457

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Figure 1. — IDO metabolites correlate with clinicopathological features of cervical cancer patients. Association between IDO activity as measured by Kyn/Trp ratio and clinicopathological parameters in cervical cancer (n = 251*). The kynurenine and tryptophan concentrations were determined by an automated online solid-phase XLC-MS/MS method with deuterated internal standards. Association of IDO activity (high Kyn/Trp ratio) and tumor size (A), FIGO stage (B), parametrium invasion (C), and lymph node metastasis (D). The non-parametric Mann-Whitney U test was used, p<0.05 was considered to be statistically significant. A high Kyn/Trp ratio was associated with tumor size (p < 0.001), advanced stage of disease (FIGO > IIA) (p < 0.001), parametrial invasion (p < 0.001) and lymph node metastases (p < 0.001). CI, confidence interval; FIGO, International Federation of Gynaecologists and Obstetricians. * For some variables, data were not available for all patients.