Table 3.

Univariate and multivariate Cox regression analysis IDO metabolites in serum (n = 251^×)

	Univariate analysis			Multivariate analysis
	HR∞	95% CI*	p value	HR∞	95% CI*	p value
Tumor size	2.40	1.44–3.98	0.001	0.88	0.51–1.54	0.66
Parametrial invasion	4.46	2.51–7.92	<0.001	1.59	0.76–3.36	0.22
FIGO stage†	5.96	3.45–10.28	<0.001	3.46	1.67–7.20	0.001
Lymph node metastasis	3.82	2.27–6.43	<0.001	2.65	1.53–4.61	0.001
Kyn/Trp ratio±	2.06	1.20–3.52	0.008	1.16	0.66–2.05	0.61

^×For some variables. data were not available for all patients.

† FIGO. International Federation of Gynecologists and Obstetricians.

±Highest quartile vs. rest.

∞ Hazard ratio.

*Confidence interval.

Patient survival rates were analyzed by univariate and multivariate Cox proportional hazards models. p < 0.05 was considered to be statistically significant.

The clinicopathological parameters tumor size. parametrial invasion. FIGO stage. lymph node metastasis and the Kyn/Trp ratio were all significantly associated with survival in an univariate Cox analysis. But. the amount of the studied IDO metabolites was not an independent prognostic factor in a multivariate Cox regression (p = 0.61).