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. 2015 Jan 7;4(3):e990773. doi: 10.4161/2162402X.2014.990773

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© M Christina Cox, Simone Battella, Raffaella La Scaleia, Sabrina Pelliccia, Arianna Di Napoli, Alessandra Porzia, Francesca Cecere, Eleonora Alma, Alessandra Zingoni, Fabrizio Mainiero, Luigi Ruco, Bruno Monarca, Angela Santoni, and Gabriella Palmieri

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Phenotypic and functional assessment of the peripheral NK cell compartment in DLBCL patients at diagnosis. Peripheral blood mononuclear cells PBMCs of newly diagnosed diffuse large B cell lymphoma (DLBCL) patients (gray boxes) and healthy age- and sex-matched controls (empty boxes) were analyzed for: (A) total lymphocyte counts, (B) natural killer (NK) cell subset absolute counts, and (C) NK cell subsets as a percentage of lymphocytes. (D) The percentage of Granzyme B-positive (GrzB⁺) cells was calculated within each NK cell subset. (E) “Natural” (anti-K562) and CD16-dependent (anti-P815 + anti-CD16 monoclonal antibody [mAb]) cytotoxic activities are expressed in lytic units at 10% cytotoxicity/10⁶ PBMC. (F) The percentage of interferon γ (IFNγ)-producing cells was calculated on gated CD3-CD56⁺ NK cells. Bars represent median gated CD3^-CD56⁺ NK cells. Bars represent median and 10–90 percentile; dots represent outliers. *P <0.05, **P ≤ 0.01, ***P < 0.0005, ****P = 0.000001.