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. 2015 Mar 6;4(2):e976057. doi: 10.4161/2162402X.2014.976057

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Figure 1. — Loss of NADPH oxidase 2 (Nox2) and sleep fragmentation (SF) accelerate tumor growth. (A) Analysis of tumor growth curves showed accelerated growth of TC1 tumors in Nox2-deficient mice (gp91^phox^-/Y-SC, n = 27 and gp91^phox^-/Y-SF, n = 35) and C57BL/6J mice (WT-SF, n = 39) when compared with control group WT-SC (n = 37). Data are shown as mean ± standard error (SE). *p < 0.05 (two-way ANOVA). (B) Tumor weight was increased at day 28 after innoculation in gp91^phox^-/Y-SC (n = 27), gp91^phox^-/Y-SF (n = 35) and WT-SF (n = 39) groups as compared with WT–SC group (n = 37). *p < 0.05 is considered significant (one-way ANOVA). (C) The number of cases manifesting tumor invasion beyong the capsular boundaries toward adjacent tissues was significantly increased in groups gp91^phox^-/Y-SC, gp91^phox^-/Y-SF and WT-SF vs. WT-SC (p < 0.05).