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Nox2 deficiency increases TAMs but does not underlie SF-induced changes in TAM polarity. Significant increases in the number of infiltrated TAMs (A) along with no changes in TAM polarity (B) emerged tumors from gp91phox-/Y-SC (n = 25), gp91phox-/Y-SF (n = 32) and WT-SF (n = 17) mice vs. WT-SC (n = 18) mice. Data are expressed as either percentages of the immediate parent population (TAM) or the ratio of CD206 MFI to CD86 MFI (polarity). *p < 0.05.
