Figure 1.

Inhibition of oncogenic BRAF^V600E in melanoma cells leads to a selective reduction in immunosuppressive T_regs and MDSCs within the tumor microenvironment. (A) Immune cell composition in Braf/Pten mouse model of BRAF^V600E-driven melanomas. Myeloid-derived suppressor cells (MDSCs) represent the dominant immune cell population; regulatory T cells (T_regs), CD8⁺ T cells and CD4⁺ effector T cells are also present. (B) BRAF^V600E-inhibition with the small molecule PLX4720 impairs the ability of melanoma cells to maintain T_reg and MDSC populations, while leaving effector T-cell populations intact.