Figure 6.

HSC-derived CCL3 mediates T cell trafficking to intracranial glioma. (A) KR158B glioma bearing mice received either wild type HSCs or (B) HSCs derived from CCL3 knockout mice directly into the glioma bed and intravenous injection of DsRed tumor-specific T cells. Intratumoral T cell infiltration was measured using fluorescent microscopy 24 h after adoptive transfer. (C) Quantification of adoptively transferred T cells within the tumor site (n = 5; Two-tailed t test, *p = 0.0219). HSCs from wildtype mice show enhanced T cell trafficking to tumor.