Fig. 3.

Schematic representation of the immunodominant region recognized by human TgAb. Only a portion of the very large Tg molecule is depicted. Four different epitope regions (A, B, C and D) on Tg are recognized by the recombinant human TgAb-Fab. The binding of TgAb to its specific epitope on Tg is inhibited by the relative TgAb-Fab. The levels of inhibition for regions A, C and D were similar in subjects using or not using IS. Interestingly, inhibition by TgAb-Fab to the epitope B was significantly higher in IS users (median 27.5%, interquartile range 6.5-48.3) than in IS non-users (3.0%, interquartile range 0.0-20.5; Mann-Whitney U test: p = 0.047).