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. 2015 Apr 15;10:2971–2984. doi: 10.2147/IJN.S75023

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© 2015 Kalita et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vivo MRSA burden reduction on topical application of CAM-PCL-P NPs.

Notes: (A) Efficacy of PCL-P NPs, free CAM, and CAM-PCL-P NPs on MRSA CFU burden of burn wound at 3 days, 7 days, 11 days, and 15 days. **Significant at P<0.01. ***Significant at P<0.001. (B) MRSA-infected burn wound over time: (a) control; (b) treated with free CAM; (c) treated with CAM-PCL-P NPs.

Abbreviations: CAM, chloramphenicol; CAM-PCL-P NPs, chloramphenicol loaded with poly(ε-caprolactone)-pluronic composite nanoparticles; CFU, colony-forming unit; MRSA, methicillin-resistant Staphylococcus aureus; PCL-P NPs, blank poly(ε-caprolactone)-pluronic composite nanoparticles.