Figure 10.

Interaction of Cu²⁺-FS with rat platelets, GPIIb/IIIa expression, and P-selectin expression.

Notes: (A) SEM image of AA-activated rat platelets with 200 nM Cu²⁺-FS, wherein the nanoparticles on the surface of the platelet are indicated by the yellow arrowheads, while the nanoparticles in the process of endocytosis are indicated by the red arrowheads. (B) SEM image of AA-activated rat platelets treated with NS. (C) GPIIb/IIIa levels of AA-activated platelets treated with 0.1–100 nM Cu²⁺-FS. (D) P-selectin levels of AA-activated platelets treated with 0.1 nM Cu²⁺-FS.

Abbreviations: AA, arachidonic acid; Cu²⁺-FS, Cu²⁺-Arg-Gly-Asp-Phe-Arg-Gly-Asp-Ser; GP, glycoprotein; NS, normal saline; SD, standard deviation; SEM, scanning electron microscope.