Table 1.

Demographic characteristics and other variables of patients with mild cognitive impairment or Alzheimer disease

	MCI (n = 51)	AD (n = 59)	P
Sex (male/female)	19/32	22/37	1.00 (0.46–2.17)
Age at diagnosis (years)	77.7 (5.0)	79.3 (6.0)	0.14
Age at onset (years)	76.0 (5.0)	77.1 (7.4)	0.69
Duration of illness (months)	18.6 (6.0)	20.0 (19.3)	0.69
Education (years)	11.4 (2.6)	10.2 (2.8)	0.03
<12	25 (49.0%)	21 (35.6%)	0.57 (0.27–1.23)
12–16	18 (35.3%)	33 (55.9%)	2.32 (1.08–5.03)
≥16	8 (15.7%)	5 (8.5%)	0.50 (0.15–1.63)
MMSE score	24.3 (2.9)	18.7 (3.2)	0.00
ADAS-J cog score	10.1 (4.6)	18.3 (6.9)	0.00
JART score	100.8 (12.8)	91.2 (13.1)	0.00
Hypertension	31 (60.8%)	27 (45.8%)	0.54 (0.25–1.16)
Diabetes mellitus	8 (15.7%)	9 (15.3%)	1.00 (0.34–2.73)
Hyperlipidemia	16 (31.4%)	10 (16.9%)	0.45 (0.18–1.10)
VSRAD Z-score	2.49 (1.31)	2.96 (1.20)	0.06
0–1	5 (9.8%)	4 (6.8%)	0.67 (0.17–2.64)
1–2	17 (33.3%)	9 (15.3%)	0.36 (0.14–0.90)
2–3	17 (33.3%)	22 (37.3%)	1.19 (0.54–2.61)
>3	12 (23.5%)	24 (40.7%)	2.22 (0.97–5.11)

Data presented as mean (SD) or n (%). P-values were calculated using the t-test or were odds ratios (95% confidence interval). ADAS-J cog, Cognitive subscale of the Japanese version of the Alzheimer's Disease Assessment Scale; JART, Japanese Adult Reading Test; MMSE, Mini-Mental State Examination; VSRAD, voxel-based specific region analysis system for Alzheimer's disease software program, where Z-scores show the degree of gray matter loss in the entorhinal and hippocampal areas (clinical criteria are: 0–1, normal; 1–2, slight; 2–3, moderate; >3, severe)