Table 1.

Regions of increased and decreased GM in the ADNI-1 compared to ADNI-2 pulse sequence

	Region	k	Z-score	x	y	z	Statistic
Increased GM
	Right temporal inferior lobe	227	10.03	64	−16	−34	P < 0.001
	Right frontal lobe	67	8.65	10	16	−28	P < 0.001
	Right medial frontal gyrus	187	8.18	2	46	26	P < 0.001
	Left supplementary motor area	103	7.78	0	−36	62	P = 0.01
	Left parietal lobe, postcentral gyrus	176	7.76	−2	−46	76	P = 0.01
	Left inferior temporal lobe	153	7.54	−64	−36	−28	P = 0.01
	Left frontal lobe, paracentral lobule	16	6.38	34	−36	62	P = 0.01
	Left frontal lobe, middle frontal gyrus	14	6.10	−26	−2	56	P = 0.02
	Right frontal lobe, superior frontal gyrus	16	6.01	2	28	48	P = 0.03
	Left cuneus	6	5.99	2	−88	30	P = 0.03
	Right frontal lobe, superior frontal gyrus	1	5.79	2	16	58	P = 0.05
Decreased GM
	Right cerebellum posterior lobe, tuber	44 701	16.63	38	−64	−38	P < 0.001
	Right frontal lobe, precentral gyrus	116	8.88	12	−24	70	P < 0.001
	Left parietal lobe, postcentral gyrus	121	8.68	−62	−10	16	P < 0.001
	Right parietal lobe, postcentral gyrus	143	8.58	62	−6	18	P < 0.001
	Right frontal lobe, orbital gyrus	155	8.56	4	38	−34	P < 0.001
	Right frontal lobe, sub-gyral	428	8.50	14	−16	48	P < 0.001
	Left occipital lobe, cuneus	111	7.60	−8	−104	−6	P = 0.001
	Left limbic lobe, cingulate gyrus	132	7.60	−8	−20	32	P = 0.001
	Left limbic lobe, anterior cingulate	357	7.25	−10	32	−6	P = 0.002
	Left frontal lobe, superior frontal gyrus	105	7.22	−26	48	44	P = 0.002
	Right frontal lobe, cingulate gyrus	9	6.57	12	24	40	P = 0.01
	Right frontal lobe, middle frontal gyrus	14	6.48	32	18	34	P = 0.01
	Right parietal lobe	8	6.27	62	−54	42	P = 0.02
	Right limbic lobe, cingulate gyrus	7	6.22	14	12	44	P = 0.02
	Right cerebellum posterior lobe	10	6.10	2	−60	−18	P = 0.02
	Right frontal lobe, middle frontal gyrus	4	6.08	58	30	26	P = 0.02
	Right frontal lobe, middle frontal gyrus	9	6.04	52	38	30	P = 0.03
	Left frontal lobe, medial frontal gyrus	4	5.99	−14	40	20	P = 0.03
	Right middle frontal gyrus	2	5.98	52	24	44	P = 0.03
	Right frontal lobe, inferior frontal gyrus	3	5.98	6−	12	38	P = 0.03
	Left frontal lobe, middle frontal gyrus	5	5.89	−34	16	34	P = 0.04
	Right limbic lobe, anterior cingulate	2	5.88	10	34	8	P = 0.04
	Right frontal lobe, medial frontal gyrus	4	5.86	18	48	8	P = 0.04
	Left parietal lobe, inferior parietal lobule	2	5.81	−58	−28	28	P = 0.04
	Right frontal lobe, superior frontal gyrus	1	5.74	26	46	48	P = 0.05

Co-ordinates are shown as MNI space. k: cluster size. Thresholding was performed at p = 0.05 (FWE correction).