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. 2015 Feb 7;110(4):658–668. doi: 10.1111/add.12827

Table 5.

The association of school dropout with adolescent substance use including different imputed covariate models.

Exposure Univariable Adjusted 1 Adjusted 2 Adjusted 3 Fully Adjusted
OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Cannabis use Ever
n = 4434 Never 2.79 1.70, 4.57 2.48 1.49, 4.12 2.55 1.53, 4.24 2.47 1.45, 4.19 2.75 1.18, 6.39
Cannabis status None
n = 4434 Non‐weekly 1.98 0.89, 4.42 1.80 0.80, 4.06 1.94 0.86, 4.41 2.48 1.05, 5.84 1.96 0.74, 5.21
Weekly 6.83 3.37, 13.85 6.24 3.02, 12.92 5.94 2.83, 12.45 5.23 2.33, 11.72 4.44 1.79, 11.00
CAST score 4+ No
n = 4137 Yes 8.15 4.00, 16.60 7.19 3.43, 15.08 7.23 3.39, 15.42 5.41 2.40, 12.20 4.40 1.70, 11.38
Smoking status None
n = 3814 Non‐daily 0.90 0.31, 2.58 0.86 0.30, 2.48 0.86 0.30, 2.50 0.86 0.29, 2.55 0.73 0.20, 2.66
Daily 7.55 4.23, 13.47 6.48 3.49, 12.04 6.17 3.29, 11.56 4.78 2.45, 9.35 2.23 1.11, 9.39
Cotinine smoking status Non‐Smoker
n = 2869 Smoker 5.44 2.85, 10.36 5.03 2.56, 9.88 4.48 2.26, 8.90 3.27 1.59, 6.70 2.54 1.12, 5.74

The educational outcome here was school dropout, which was derived from not gaining any General Certificate of State Education (GCSE) grades or receiving only U grades (graded as unclassified); four covariate models were used and each builds on the previous model. These models are grouped into proximal and distal determinants. Adjustment 1 model includes binary maternal substance use behaviours (mother smokes, mother binge drinks and mother uses cannabis). Adjustment 2 model included demographics [socio‐economic status (SES), maternal education and income] and sex. Adjustment 3 model includes the individuals previous education before substance use is more likely [standard deviation (SD) change for Key Stage 2 English and Mathematics]. The fully adjusted model includes child's substance use behaviour measured at the same time as the exposure (child drinking, child weekly cannabis use for the tobacco smoking exposures and child smoking for the cannabis use exposures) and conduct disorder. Covariates were imputed to increase n. All the testparm results were P < 0.001. CAST = Cannabis Abuse Screening Test; CI = confidence interval; OR= odds ratio.