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. Author manuscript; available in PMC: 2015 Apr 21.
Published in final edited form as: Leukemia. 2013 Oct 22;28(2):457–460. doi: 10.1038/leu.2013.301

Figure 2. HDAC6 inhibitor combined with carfilzomib triggers ER stress followed by intrinsic apoptotic pathway.

Figure 2

RPMI8226 cells were treated with control media (C), ACY-1215 (ACY, 2 µM), or MS275 (MS, 2 µM), in the absence or presence of CFZ (10 nM) for 16h. (A and C) Cell lysates were subjected to Immunoblotting with indicated Abs; CF, cleaved fragment. (B) Total RNA was extracted; XBP1 and β-actin mRNA were evaluated by RT-PCR.