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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Brain Behav Immun. 2014 Dec 3;45:189–197. doi: 10.1016/j.bbi.2014.11.011

Figure 5. Tonic GABAergic signaling is altered in specific CeA cell types fromIl1rn KO compared to WT mice.

Figure 5

A) Representative recordings from a Low Threshold Bursting (LTB) neuron from a WT (upper trace) and Il1rn KO mouse (lower trace) during focal application of gabazine (GBZ, 100 μM). Dashed lines indicate average holding current. B) Summary of the tonic current in LTB neurons from WT (white bar) and KO mice (black bar) revealed by application of GBZ (n=7for both genotypes; *p<0.05, unpaired t-test). C) Recordings from a Late Spiking (LS) neuron from a WT (upper trace) and Il1rn KO mouse (lower trace) during application of GBZ. Dashed lines indicate average holding current. D) Summary of the tonic current in LS neurons from WT (white bar) and Il1rn KO mice (black bar) revealed by application of GBZ (n=6 (WT), n=5 (Il1rn KO); *p<0.05, unpaired t-test). E)Summary of the tonic current in LTB and LS neurons from WT (white bars) and Il1rn KO mice (black bars) revealed by focal application of 5 μM THIP (n=6–7; *p<0.05, one-way ANOVA with Bonferroni post hoc comparison). F)Summary of the tonic current in LTB and LS neurons from WT (white bars) and Il1rn KO mice (black bars) revealed by focal application of 44 mM EtOH(n=5–6; *p<0.05, one-way ANOVA with Bonferroni post hoc comparison).