Table 2.
Glutathione levels in placebo and Alda-1-treated post-MI cardiomyopathy rats
Parameter | Sham | Post-MI cardiomyopathy
|
|
---|---|---|---|
Placebo | Alda-1 | ||
|
|
||
GSH (nmol/mg) | 3.06±0.44 | 4.29±0.21* | 3.31±0.14‡ |
GSSG (nmol/mg) | 0.36±0.03 | 0.61±0.05* | 0.47±0.04 |
GSH/GSSG | 8.34±0.82 | 7.14±0.48 | 7.56±1.15 |
|
|
Measurements of reduced glutathione (GSH), oxidized glutathione (GSSG) and reduced:oxidized glutathione ratio in cardiac sample from Sham (n=5), post-MI placebo (4 wks after MI, n=5) and post-MI Alda-1 treated (4 wks after MI, n=7) animals. Animals were treated for 4wks, starting 24hrs after permanent LAD occlusion surgery. Data were analyzed by one-way ANOVA followed by post-hoc Duncan. Error bars indicate SEM.
p<0.05 vs. control (sham);
p<0.05 vs. Post-MI Placebo rats.