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. Author manuscript; available in PMC: 2015 Apr 21.
Published in final edited form as: Clin Immunol. 2008 Jun 2;128(2):133–147. doi: 10.1016/j.clim.2008.03.525

Figure 2.

Figure 2

HCV RNA induces activation of IRF-3 via both the RIG-I and TLR3 pathways. Activated IRF-3 leads to IFNβ production and secretion from infected cell. HCV NS3/4A serine protease blocks these two pathways by cleavage of IPS-1 and TRIF.