Table 3.

Heterogeneity test of SNP effect between A) asthmatic and non-asthmatic adult groups, B) atopic and non-atopic adult groups and C) according to tobacco smoke exposure for the two SNPs for which increased evidence of association was observed in the combined meta-analysis of adult discovery and replication sets^a

	Part A						Meta-analysis Asthmatic subjects (N=417)		Meta-analysis Non-asthmatics (N=994)		Test for heterogeneity between groups
Chr	Gene	Previous Gene	Next Gene	SNP	Positionb	Base/Alt Allele	Z-score	P-value	Z-score	P-value	Chi2	P-value
2		SLC8A1	HNRNPA1P57	rs2194437	41343221	G/C	−3.01	0.003	−3.28	0.001	0.23	0.63
15	RAB27A			rs2444043	55534342	C/T	1.62	0.11	4.86	1.2×10−6	1.57	0.21
	Part B						Atopic subjects (N=657)		Non-atopic subjects (N=533)
2		SLC8A1	HNRNPA1P57	rs2194437	41343221	G/C	−4.12	3.8×10−5	−2.24	0.03	3.07	0.08
15	RAB27A			rs2444043	55534342	C/T	2.59	0.009	3.75	1.8×10−4	2.94	0.08
	Part C						Current & Ex-smokers (N=475)		Never smokers (N=1,185)
2		SLC8A1	HNRNPA1P57	rs2194437	41343221	G/C	−2.56	0.01	−4.91	9.2×10−7	3.32	0.06
15	RAB27A			rs2444043	55534342	C/T	3.00	0.003	4.08	4.4×10−5	2.38	0.12
							Current smokers (N=220)		Ex- & never smokers (N=1,440)
2		SLC8A1	HNRNPA1P57	rs2194437	41343221	G/C	−2.79	0.005	−4.26	2.0×10−5	1.33	0.25
15	RAB27A			rs2444043	55534342	C/T	1.77	0.08	4.70	2.6×10−6	1.96	0.16

^aTalana data were not used in the atopy stratified analysis since skin prick tests were only measured in 190 subjects having an Allergy & Asthma questionnaire score ≥5.

^bPosition in base pairs (bp) – build 37.3 NCBI