Figure 4. Conservation of TF-to-TF regulatory circuitry.
a, Four categories of regulatory interactions identified by comparative analysis of mouse and human TF networks. Functionally conserved connections can be mediated by TF occupancy at orthologous (red) or non-orthologous (blue) binding sites. b, Categorization and overall conservation of TF-to-TF connections between orthologous mouse and human cell types. On average 44% of TF-to-TF edges are conserved (P < 0.001; empirically calculated using shuffled networks).