Table 2.
Grade 2 or Higher Toxic Effects.*
| Adverse Event | Chemotherapy Alone (N = 111) | Chemotherapy plus Goserelin (N = 103) | ||||
|---|---|---|---|---|---|---|
| Grade 2 | Grade 3 | Grade 4 | Grade 2 | Grade 3 | Grade 4 | |
| Diarrhea | 2 | 0 | 0 | 0 | 0 | 0 |
|
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| Fatigue | 1 | 0 | 0 | 2 | 0 | 0 |
|
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| Hot flashes | 14 | 3 | 0 | 29 | 4 | 0 |
|
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| Irregular menses | 2 | 0 | 0 | 5 | 2 | 0 |
|
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| Decrease in libido | 6 | 0 | 0 | 9 | 0 | 0 |
|
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| Agitation | 4 | 1 | 0 | 6 | 0 | 0 |
|
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| Anxiety | 4 | 0 | 0 | 9 | 0 | 0 |
|
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| Depression | 3 | 0 | 0 | 8 | 1 | 0 |
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| Joint pain | 1 | 1 | 0 | 0 | 0 | 0 |
|
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| Muscle pain | 2 | 0 | 0 | 1 | 0 | 0 |
|
| ||||||
| Headache | 1 | 1 | 0 | 12 | 0 | 0 |
|
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| Sweating | 7 | 0 | 0 | 10 | 0 | 0 |
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| Thromboembolism | 0 | 0 | 0 | 0 | 0 | 1 |
|
| ||||||
| Vaginal dryness | 9 | 0 | 0 | 12 | 0 | 0 |
*
Included are grade 2 or higher toxic effects that were reported in more than 1% of the patients in either study group. Patients may have had more than one toxic event for a given grade.