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. 2015 Apr 21;11(4):e1005150. doi: 10.1371/journal.pgen.1005150

Fig 8. Model for DDR and SAC interactions throughout the cell cycle.

Fig 8

During metaphase disruptions (left), ATR (green), P-CHK-1(Ser344) (orange), MAD-1 (yellow), MAD-2 (purple), and CENPA (blue) localize to chromatin and are required for metaphase delay and stable arrest. In response to DNA damage (right), RAD-51 (red), MAD-1, MAD-2, and CENPA localize to the nuclear periphery (NPC, light green). The localization of MAD-2 is dependent on ATR and MAD-1. Additionally, the localization of CENPA is dependent on ATR, MAD-1 and MAD-2. All of these components are required for efficient DNA repair.