Fig. 2.

Pathological features of sIBM: a partial invasion of a myofiber by inflammatory cells (Gomori trichrome; original magnification ×600). b Intracytoplasmic rimmed vacuoles (H&E; original magnification ×400). c Evidence of intracytoplasmic and intravacuolar amyloid by staining with pFTAA (original magnification ×400). d Intracytoplasmic paired helical filaments illustrated by ultrastructural examination (scale bar represents 0.5 μm). e, f Immunohistochemical evidence of P62⁺ aggregates in muscle fibres (e original magnification ×400, f original magnification ×200)