Figure 2.

Effect of MFE on neuronal activity loss induced by high-fat diet in CA3 region of the hippocampus. The recovery effect of MFE on high-fat diet-induced dysfunction of neural activity was investigated using c-Fos immunohistochemistry (f). Representative photomicrographs are shown for the CA3 region of each group ((a)–(e)): (a) normal groups; (b) high-fat diet group; ((c), (d), and (e)) high-fat diet/MFE group (0.2, 0.5, and 1 g/kg/day treated, resp.). Scale bar = 200 μm. Values are expressed as the mean ± SEM (n = 6 mice per group). ^∗∗∗ P < 0.001 as compared to the normal group. ^## P < 0.01 as compared to the high-fat diet group.