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. 2015 Apr 16;58(2):371–386. doi: 10.1016/j.molcel.2015.02.002

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Analysis of Histone Modification Dynamics

(A) Extraction of kinetic parameters from time course data. RNA abundance and the indicated modification levels for the GLK1 +1 nucleosome. For each time course we extracted the maximal response (h) and the time to half-maximal response (t_1/2).

(B) Comparison of measurements with extracted kinetic data, with rows showing individual genes. (Left panel) Time course data for H3K23ac levels at the +1 nucleosome sorted by t_1/2; (middle panel) interpolated data; (right panel) mRNA abundance changes.

(C) Genome-wide kinetic offsets for up- and downregulated genes. For each modification, boxplot of the t_1/2 is shown for up- or downregulated genes, as indicated.